CYCLICAMINE DERIVATIVE AS A MEANS OF STIMULATION OF THE ACTION OF ADVILLIN AND A NEW CYCLICAMINE DERIVATIVE AND ITS APPLICATION IN PHARMACEUTICALS Russian patent published in 2023 - IPC A61K31/454 A61K31/496 A61K31/5377 A61P25/02 A61P3/00 A61P43/00 C07D401/06 

FIELD: pharmaceuticals.

SUBSTANCE: invention is related namely to the use of an agent containing a cyclic amine derivative or a pharmacologically acceptable salt thereof for stimulating the action of advillin, a cyclic amine derivative and a drug for reducing anomalies in the regulation of actin filament turnover. Use of an agent comprising a cyclic amine derivative having the following general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient:

,

where the carbon atom marked with * denotes an asymmetric carbon atom and A denotes a group described by the following general formula (IIa) or (IIb):

,

where R¹ is a methyl group, an n-propyl group, an isopropyl group, a 2-methoxyethyl group or a 3,3,3-trifluoropropyl group, R² is a hydrogen atom or a chlorine atom, each R³ is independently a methyl group or an ethyl group, and Xmeans -O- or -N(R³ )-, to stimulate the action of advillin. A cyclic amine derivative which is a single compound selected from the group consisting of the following: 3-hydroxy-3-(1-methyl-1H-imidazol-2-yl)-1-(4-morpholinopiperidin-1-yl)propan-1-one, 1-(4-(dimethylamino)piperidin-1-yl )-3-(1-propyl-1H-imidazol-2-yl)-3-hydroxypropan-1-one, 1-(4-(dimethylamino)piperidin-1-yl)-3-(1-isopropyl-1H- imidazol-2-yl)-3-hydroxypropan-1-one, 3-(5-chloro-1-methyl-1H-imidazol-2-yl)-1-(4-(dimethylamino)piperidin-1-yl)- 3-hydroxypropan-1-one, 1-(4-(dimethylamino)piperidin-1-yl)-3-(1-(2-methoxyethyl)-1H-imidazol-2-yl)-3-hydroxypropan-1-one and 1-(4-(dimethylamino)piperidin-1-yl)-3-(1-(3,3,3-trifluoropropyl)-1H-imidazol-2-yl)-3-hydroxypropan-1-one, or its pharmacologically acceptable salt. A drug for reducing an abnormality in regulation of actin filament turnover, comprising the above cyclic amine derivative or a pharmacologically acceptable salt thereof as an active ingredient.

EFFECT: group of inventions makes it possible to stimulate the action of advillin and provide treatment for axon damage.

12 cl, 5 dwg, 5 tbl, 17 reference ex, 14 ex