MACROCYCLIC COMPOUND AND ITS USE Russian patent published in 2022 - IPC C07D493/22 A61K31/357 A61P35/00 

Abstract RU 2783238 C2

FIELD: medicine.

SUBSTANCE: invention relates to a new compound (1) characterized by an effect of remodeling tumor vessels and/or activity against cancer-associated fibroblasts (CAF) or its pharmaceutically acceptable salt, as well as to a pharmaceutical composition based on it, and the use for the treatment of tumor or cancer.

EFFECT: new compound is obtained, which can be used for the treatment of tumor or cancer, wherein cancer or tumor is head and neck cancer, breast cancer, esophageal cancer, uterine cancer, ovarian cancer, colon and rectal cancer, endometrial cancer, stomach cancer, small bowel cancer, bladder cancer, or sarcoma.

78 cl, 27 ex, 17 tbl, 18 dwg

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RU 2 783 238 C2

Authors

Kishi, Joshito

Kira, Kazunobu

Ito, Ken

Dates

2022-11-10Published

2018-04-03Filed