FIELD: chemistry.
SUBSTANCE: invention relates to a method for producing derivatives of tetrazolo[5,1′′:3,4]pyrazino[1,2-a]indole with the general formula
including the reaction of N-(propargyl)indole-2-carbonitrile, unsubstituted or substituted with methyl or chlorine in the 5′-position, with sodium azide in the presence of L-proline in DMF, holding at 130 °C for 15 hours followed by filtering, washing with water and methanol, and air drying resulting in tetrazolo[5,1′′:3,4]pyrazino[1,2-a]indole, unsubstituted or substituted with methyl or chlorine in the 5′-position.
EFFECT: convenient method developed for producing derivatives of tetrazolo[5,1′′:3,4]pyrazino[1,2-a]indole as a result of the reaction of N-(propargyl)indole-2-carbonitrile with sodium azide, catalysed with L-proline.
1 cl, 3 ex
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