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2 787 273

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(51)

IPC

G01N33/52(2006-01-01)

G01N33/49(2006-01-01)

C12Q1/6804(2018-01-01)

C12Q1/6827(2018-01-01)

C12Q1/6876(2018-01-01)

C12Q1/6883(2018-01-01)

(21) (22)

Application

2022105846, 2022-03-04

(24)

Start date

2022-03-04

(22)

Actual filing date

2022-03-04

(45)

Published

2023-01-09

(72)

Inventor

Azarova Iuliia EduardovnaKlesova Elena IurevnaPolonikov Aleksei Valerevich

(73)

Holder

Federalnoe Gosudarstvennoe Biudzhetnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniia Gosudarstvennyi Meditsinskii Universitet" Ministerstva Zdravookhraneniia Rossiiskoi Federatsii

METHOD FOR PREDICTING THE RISK OF DEVELOPING DIABETIC DISTAL POLYNEUROPATHY IN WOMEN WITH TYPE 2 DIABETES MELLITUS BASED ON RS7784465 GENOTYPING OF THE RAC1 GENE POLYMORPHISM RS7784465 Russian patent published in 2023 - IPC G01N33/52 G01N33/49 C12Q1/6804 C12Q1/6827 C12Q1/6876 C12Q1/6883

Abstract RU 2787273 C1

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to medical diagnostics, and can be used to predict the risk of developing diabetic distal polyneuropathy in women with type 2 diabetes mellitus. A sample of peripheral venous blood is taken. After DNA extraction, a polymorphic variant of the small GTPase gene RAC1 rs7784465 (T>C) is analyzed. If the rs7784465-C allele is detected, an increased risk of developing diabetic distal polyneuropathy in women with type 2 diabetes is predicted. When the rs7784465-T/T genotype is detected, a low risk of developing diabetic distal polyneuropathy in women with type 2 diabetes is predicted.

EFFECT: method provides for obtaining new criteria for assessing the risk of developing diabetic peripheral neuropathy in women of Central Russia with type 2 diabetes mellitus according to the genetic polymorphism rs7784465 (T>C).

1 cl, 1 dwg, 1 tbl

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RU 2 787 273 C1

Authors

Azarova Iuliia Eduardovna

Klesova Elena Iurevna

Polonikov Aleksei Valerevich

Dates

2023-01-09—Published

2022-03-04—Filed