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2 786 820

(13)

(51)

IPC

G01N33/52(2006-01-01)

G01N33/49(2006-01-01)

C12Q1/6804(2018-01-01)

C12Q1/6827(2018-01-01)

C12Q1/6876(2018-01-01)

C12Q1/6883(2018-01-01)

(21) (22)

Application

2022106505, 2022-03-14

(24)

Start date

2022-03-14

(22)

Actual filing date

2022-03-14

(45)

Published

2022-12-26

(72)

Inventor

Azarova Iuliia EduardovnaKlesova Elena IurevnaPolonikov Aleksei Valerevich

(73)

Holder

Federalnoe Gosudarstvennoe Biudzhetnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniia Gosudarstvennyi Meditsinskii Universitet" Ministerstva Zdravookhraneniia Rossiiskoi Federatsii

METHOD FOR PREDICTING THE RISK OF DEVELOPING DIABETIC RETINOPATHY IN MEN WITH TYPE 2 DIABETES MELLITUS BASED ON RS836478 POLYMORPHISM GENOTYPING IN THE RAC1 GENE Russian patent published in 2022 - IPC G01N33/52 G01N33/49 C12Q1/6804 C12Q1/6827 C12Q1/6876 C12Q1/6883

Abstract RU 2786820 C1

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to medical diagnostics, and can be used to predict the risk of developing diabetic retinopathy in men with type 2 diabetes. A sample of peripheral venous blood is taken. After DNA extraction, a polymorphic variant of the small GTPase gene RAC1 rs836478 (C>T) is analyzed. If the rs836478-T/T genotype is detected, an increased risk of developing diabetic retinopathy in men with type 2 diabetes is predicted. When genotypes rs836478-C/T and rs836478-C/C are detected, a low risk of developing diabetic retinopathy in men with type 2 diabetes is predicted.

EFFECT: method provides for obtaining new criteria for assessing the risk of developing diabetic retinopathy in men of Slavic ethnicity with type 2 diabetes mellitus according to the genetic polymorphism rs836478 (C>T).

1 cl, 1 dwg, 1 tbl

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RU 2 786 820 C1

Authors

Azarova Iuliia Eduardovna

Klesova Elena Iurevna

Polonikov Aleksei Valerevich

Dates

2022-12-26—Published

2022-03-14—Filed