VACCINE TO SWINE INFLUENZA A VIRUS Russian patent published in 2023 - IPC A61K39/193 

FIELD: biotechnology; veterinary medicine.

SUBSTANCE: vaccine for help in prevention of a disease caused by an influenza virus is presented, containing two or more RNA replicon particles (RP), each of which independently encodes one or more neuraminidases (hereinafter – NA), and a pharmaceutically acceptable carrier. In this case, the first particle of alphavirus RNA replicon encodes the first NA, and the second particle of alphavirus RNA replicon encodes the second NA, or the particle of alphavirus RNA replicon encodes two and more NA, provided that an immunogenic composition does not contain either hemagglutinin (hereinafter – HA) of a swine influenza A virus (hereinafter – IAV-S), or a nucleotide sequence encoding HA of IAV-S. The first NA and the second NA contain amino acid sequences, which are 98% or less identical. A method for immunization of a swine against a swine influenza A virus, including administration to the swine of immunologically effective amount of the claimed vaccine, and the use of a vaccine for help in prevention of a disease caused by a swine influenza A virus in swine are also presented.

EFFECT: vaccine to IAV-S, containing and/or encoding a neuraminidase antigen of an influenza A virus in the absence of the corresponding hemagglutinin antigen, can adequately protect a swine from IAV-S infection.

16 cl, 8 tbl, 15 dwg, 6 ex