SWINE INFLUENZA VIRUS VACCINE CONTAINING TWO DIFFERENT RNA REPLICON PARTICLES Russian patent published in 2025 - IPC A61K39/145 A61P31/16 

FIELD: medicine; biotechnology.

SUBSTANCE: present invention relates to medical biotechnology. Presented is an immunogenic composition. Composition contains first and second RNA replicon particles. First replicon RNA particle comprises a nucleic acid construct comprising first and second nucleic acid sequences encoding first and second antigens, haemagglutinins (HA), of swine influenza A virus (IAV-S), where the first HA antigen relates to the H3N2 line, similar to A/swine/Gent/1/1984 (Gent/84), and the second HA antigen relates to the A (H1N1) pdm09 (pdm09) line, the second RNA replicon particle comprises a nucleic acid construct , containing third and fourth nucleic acid sequences, HA IAV-S third and fourth antigens, where the third HA antigen relates to the H1_huN2 line, similar to A/swine/Scotland/410440/1994 (Scot/94), and the fourth HA antigen relates to the H1_avN1 line, similar to the EURASIA avian strain (EA), and where the RNA replicon particle is an alphavirus RNA replicon particle. Invention discloses a vaccine, a method for immunization of swine against swine influenza A virus.

EFFECT: invention enables producing the swine influenza A virus vaccine.

16 cl, 14 dwg, 7 tbl, 7 ex