METHOD FOR PREDICTING THE APPEARANCE OF DISTANT METASTASES OF MELANOMA OF THE CHOROID Russian patent published in 2023 - IPC G01N33/50 A01B5/00 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to diagnostics in the field of oncology, and can be used to predict the appearance of distant metastases of choroidal melanoma in the process of intravital pathological and anatomical examination of the tumor. The method includes immunohistochemical examination of the tumor using a combination of markers CD 4, CD 68, Macrophage, CD 34. T-lymphocytes of helpers/inducers, macrophages, volumetric density of blood vessels are quantified in melanoma of the choroid, based on the indicators of which a model for predicting the appearance of distant metastases is derived. melanoma of the choroid, and the probability of occurrence of distant metastases CM (P) according to the formula. At the same time, the probability of occurrence of distant metastases CM is defined as high if P>0.5, and if P≤0.5, the probability is defined as low.

EFFECT: invention provides the possibility of predicting the appearance of distant CM metastases based on the quantitative indicators of lymphocytes and macrophages, the volumetric density of blood vessels in the tumor; method is informative and can be applied in the work of physicians at the stage of surgical treatment of choroidal melanoma (CM) during an intravital pathological and anatomical study of the surgical material of enucleated eyes based on the developed model for predicting the appearance of distant CM metastases, which has a sensitivity of 83.3% and a specificity of 92% allows predicting the appearance of secondary tumor foci.

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