FIELD: pharma chemistry.
SUBSTANCE: group of inventions includes a compound of formula
where X is bromine or hydroxy, as well as a method for obtaining a compound of formula (III). The method is carried out by obtaining a bromine derivative of compound 10 which is further subjected to 18-F fluorination. In the formula (III) R3 represents a group selected from
.
EFFECT: intermediate compounds for the preparation of a visualizing agent for tau proteins having improved metabolic and stability properties in vivo.
,
12 cl, 11 dwg, 2 tab, 6 ex
Title | Year | Author | Number |
---|---|---|---|
DEUTERATED HETEROCYCLIC COMPOUNDS AND USE THEREOF AS IMAGING MEANS | 2015 |
|
RU2696492C2 |
CHEMICAL COMPOUNDS-759 | 2008 |
|
RU2481348C2 |
FLUORINE-18 AND CARBON-11 LABELED RADIOLIGANDS FOR POSITRON EMISSION TOMOGRAPHY (PET) IMAGING FOR LRRK2 | 2012 |
|
RU2650641C2 |
PYRAZOLAMINOPIRIMIDINE DERIVATIVES AS LEUCINE-REPEATING KINASE 2 (LRRK2) MODULATORS FOR TREATMENT OF PARKINSON DISEASE | 2013 |
|
RU2637948C2 |
INHIBITOR CONTAINING BICYCLIC DERIVATIVE, METHOD OF PREPARATION AND USE THEREOF | 2020 |
|
RU2820948C2 |
1,2,4-TRIAZINE-6-ONE DERIVATIVES, INHIBITING HIV | 2005 |
|
RU2401833C2 |
DERIVATIVES OF BENZIMIDAZOL, COMPOSITIONS CONTAINING THEM, OBTAINING AND APPLICATION | 2004 |
|
RU2346938C2 |
HIV-INHIBITING 5-CARBO- OR HETEROCYCLIC SUBSTITUTED PYRIMIDINES | 2005 |
|
RU2403244C2 |
METHOD FOR PREPARING DIHYDROINDENAMIDE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND USING THEM AS PROTEIN KINASE INHIBITOR | 2009 |
|
RU2528408C2 |
INTERMEDIATE COMPOUNDS AND METHODS OF OBTAINING 4-(ACETYLAMINO)-3-[(4-CHLOROPHENYL)THIO]-2-METHYL-1H-INDOLE-1-OF ACETIC ACID | 2010 |
|
RU2551852C2 |
Authors
Dates
2023-03-14—Published
2015-05-12—Filed