DEUTERATED HETEROCYCLIC COMPOUNDS AND USE THEREOF AS IMAGING MEANS Russian patent published in 2019 - IPC C07D221/08 C07D401/04 C07D417/04 C07D471/14 C07B59/00 C07D487/04 C07D519/00 A61K51/04 A61K31/519 A61P25/28 A61P43/00 A61K49/10 

FIELD: chemistry.

SUBSTANCE: present invention relates to a deuterated compound of formula (Ie):

, where carbon marked with * has a factor of deuterium isotope enrichment of at least 3500 and a deuterated compound which is compound:

Also disclosed is a pharmaceutical composition for detecting amyloid plaques and/or aggregation of tau protein in an animal, comprising said deuterated compounds, as well as methods of using such compounds for detecting neurofibrillar tangles and/or senile plaques in an animal, for detecting a disease of the nervous system associated with amyloid plaques and/or aggregation of tau protein in an animal, for detecting Alzheimer's disease associated with amyloid plaques and/or aggregation of tau protein in animals.

EFFECT: technical result is obtaining a visualizing agent for tau proteins, having improved metabolic characteristics and stability properties in vivo.

17 cl, 10 dwg, 2 tbl, 6 ex