BIO-INK COMPOSITION FOR REGENERATION OF CARTILAGE, METHOD FOR MANUFACTURE OF INDIVIDUALIZED FRAME FOR REGENERATION OF CARTILAGE, USING IT, AND INDIVIDUALIZED FRAME FOR REGENERATION OF CARTILAGE, MADE USING MANUFACTURING METHOD Russian patent published in 2023 - IPC A61L27/38 A61L27/22 A61L27/54 A61F2/30 B33Y80/00 

FIELD: pharmaceutics.

SUBSTANCE: group of inventions relates to pharmaceutics, namely to bio-ink for regeneration of the cartilage, as well as to a method for the manufacture of an individual frame for regeneration of the cartilage. A bio-ink composition for regeneration of the cartilage includes the first liquid containing a stromal-vascular fraction obtained from adipose tissue, hyaline cartilage powder, and fibrinogen; and the second liquid containing thrombin, in which a concentration of the stromal-vascular fraction obtained from adipose tissue in the first liquid is from 10⁵ to 10⁷ cells/ml, in which a concentration of hyaline cartilage powder is from 0.005 to 0.1 wt./vol.%, and in which a diameter of particles of hyaline cartilage powder is from 30 to 300 mcm. A method for the manufacture of an individual frame for regeneration of the cartilage, using 3D printer and a bio-ink composition, is also described.

EFFECT: proposed group of inventions provides treatment of the cartilage due to an increase in a capability of an implanted stromal-vascular fraction obtained from adipose tissue of differentiation into the cartilage, and due to enhancing of a cartilage regeneration process at an implantation site, using one surgical procedure.

10 cl, 14 dwg, 5 ex