FIELD: biotechnology.
SUBSTANCE: invention concerns a new strain of foot-and-mouth disease virus Aphtae epizooticae genotype O/EA-3, Picornaviridae family, genus Aphthovirus, deposited in the All-Russian State Collection of Exotic Types of Foot-and-Mouth Disease Virus and Other Animal Pathogens (GKShM) FSBI ARRIAH under registration number No.481 - dep/23-31 — GKShM FSBI ARRIAH strain “O No. 2241/Ethiopia/2011” genotype O/EA-3 of foot-and-mouth disease virus. The presented strain is reproduced in transplanted cell cultures of Siberian Mountain Ibex Kidney (PSGK-30), Pig Kidney (IB-RS-2), and Newborn Syrian Hamster Kidney (ВНК-21). In a continuous suspension culture of Syrian hamster kidney cells BNK-21/SUSP/ARRIAH for 10.30± 0.42 hours of incubation, the concentration of the 146S component of the strain O No. 2241/Ethiopia/2011 genotype O/EA-3 of the foot-and-mouth disease virus has an average value of 1.69±0.21 μg/cm3 (68.40±1.00%), maintaining the initial characteristics when passaging in the continuous suspension cell line VNK-21/SUSP/ARRIAH.
EFFECT: presented O No. 2241/Ethiopia/2011 strain can be used for the manufacture of biopreparations for the diagnosis and specific prevention of FMD genotype O/EA-2241 and to control the antigenic activity of FMD vaccines.
1 cl, 1 dwg, 3 tbl, 5 ex
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