METHOD FOR PRODUCING A CALCIUM PHOSPHATE MATRIX BASED ON A SELF-ADHESIVE COMPOSITION WITH ANTIBACTERIAL PROPERTIES FOR CORRECTING THE PATHOLOGY OF THE PATIENT'S MUSCULOSKELETAL SYSTEM Russian patent published in 2023 - IPC A61L24/02 A61L27/12 A61K31/7036 A61K38/14 

FIELD: medicine.

SUBSTANCE: invention relates to surgical osteology, and can be used in surgical treatment of patients with bone tissue damage in trauma-orthopedic, dental, surgical and other hospitals. A method for producing a calcium phosphate matrix based on a self-adhesive composition with antibacterial properties for correcting the pathology of the patient's musculoskeletal system includes mixing initial powders containing as a base α-tricalcium phosphate with a powder particle size of 5 to 20 microns, 2.0–15.6 wt.% of the aminoglycoside and/or glycopeptide powder as an antibacterial agent and 2.8–31.6 wt.% of polyethylene glycol granules with a granule size of 100–400 microns with a mixing liquid, which is used as distilled water or a 5% solution of sodium hydrogen phosphate 12-water. The ratio of mixing liquid to the said powder mixture is chosen to be 0.2. Then the resulting mass of the mixture of the initial powders with the mixing liquid is molded using pressing under a pressure of 130 MPa. The resulting calcium phosphate matrix is kept at a temperature of 20–60°C for 24 hours at 100% humidity, the polyethylene glycol granules are extracted with chloroform at 65°C and purified in supercritical CO₂ in a reactor with stirring for 8 hours at a temperature of 60°C and a pressure of 10 MPa to obtain the final product.

EFFECT: invention provides for obtaining a calcium phosphate matrix with antibacterial properties, which has the ability to grow blood vessels and newly formed bone tissue when replacing bone defects of the human musculoskeletal system, as well as sufficient and required osseointegration at the interface of the implant contact with the patient's bone tissue while providing antimicrobial activity in the implantation zone.

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