FIELD: biotechnology.
SUBSTANCE: different variants of a method for improving the pharmacokinetics of an antigen-binding molecule are proposed, where the method includes modification of the Fc region of the antigen-binding molecule. The antigen-binding molecule is a human IgG antibody containing an antigen-binding domain whose antigen-binding activity varies with pH and an Fc region having an FcRn binding activity at pH 7.4.
EFFECT: invention has demonstrated that modification of the Fc region of an antigen-binding molecule to an Fc region that does not form in the neutral pH range a heterotetrameric complex containing two FcRn molecules and an active Fcγ-receptor, improved the pharmacokinetics of the antigen-binding molecule and reduced the immune response to the antigen-binding molecule.
5 cl, 65 dwg, 84 tbl, 14 ex
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