METHOD FOR OBTAINING 1-PHENYL-1-BORASPYROALKANE Russian patent published in 2023 - IPC C07F5/02 A61K31/69 

FIELD: chemistry.

SUBSTANCE: present invention relates to a method for obtaining new organoboron compounds, namely, to a method for obtaining 1-phenyl-1-borospiroalkanes of general formula (1a-c), where (a) n = 1, (b) n = 3, (c) n = 7. The proposed method is carried out by the interaction of phenyldichloroborane PhBCl₂ with methylenecycloalkane (methylenecyclohexane, or methylenecyclooctane, or methylenecyclododecane) when cooled to 0°C for 1 h in the presence of a Cp₂TiCl₂ catalyst and Mg powder at a molar ratio of PhBCl₂:methylenecycloalkane: Mg : Cp₂TiCl₂ = (9÷11) : 10 : 10 : (1.5÷ 2.5) in tetrahydrofuran in an inert atmosphere and further stirring at room temperature 20−22°C for 4–8 hours. The total yield of target products is 70–80%.

EFFECT: precursors for the creation of new drugs in the form of boric acid derivatives, as well as building blocks for the creation of new π-coupled organic photophysical and electronic devices.

1 cl, 1 tbl, 3 ex