METHOD FOR PRODUCING SPIRO[ADAMANTANE-2,2'-BORIRANES] Russian patent published in 2023 - IPC C07F5/02 

FIELD: organoboron compounds production.

SUBSTANCE: present invention relates to methods for obtaining new framework organoboron compounds, namely to a method for producing spiro[adamantane-2,2'-boriranes] of formula (1a,b). According to the proposed method, dichloroborane RBCl₂⋅SMe₂, where R = cyclooctyl or exonorbornyl, previously obtained by the reaction of cis-cyclooctene or norbornene with НBCl₂⋅SMe₂ at room temperature approximately 20‒22°C in an inert atmosphere for 4 h, interacts with methylidenadamantane in the presence of a catalyst Cp₂TiCl₂ and Mg powder at a molar ratio of RBCl₂⋅SMe₂:methylideneadamantane:Mg:Cp₂TiCl₂ = (10÷12):10:10:(1.8÷2.2) in tetrahydrofuran and an inert atmosphere at a temperature of about 60°C for 6-8 hours subsequent oxidation with atmospheric oxygen.

EFFECT: resulting organoboron compounds can be used in medicinal chemistry as a synthetic block in the creation of drugs based on framework derivatives of boric acids.

1 cl, 1 tbl, 2 ex