FIELD: anti-viral formulas.
SUBSTANCE: invention is related to a process for preparation of pyrrolo[1,2-f]phenanthridine derivatives with the general formula
1) R=CH3, R1= R2=Н; 2) R=CH3, R1=Н, R2=СН3; 3) R= R1=ОСН3, R2=Н; 4) R=R1=ОСН3, R2=СН3, which are structural analogues of compounds exhibiting antiviral, anti-HIV and cytotoxic activity. The method is characterized by the fact that 6-aroylphenanthridines are dissolved in trifluoroethanol and acrolein or methyl vinyl ketone are added, then subjected to microwave activation at a temperature of +180°C; the residue obtained after completion of the reaction and removal of the reagents is crystallized from cold ether.
EFFECT: new method for obtaining pyrrolo[1,2-f]phenanthridine derivatives has been developed, which is convenient and effective for obtaining a hard-to-reach and promising series of compounds that potentially have antiviral and cytotoxic activity.
1 cl, 4 ex
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