METHOD FOR OBTAINING 3-HETARYL-7-AMINOCUMARINS Russian patent published in 2023 - IPC C07D405/04 C07D405/14 C07D491/22 C07D409/14 C07B37/02 

FIELD: chemistry.

SUBSTANCE: process for the preparation of a compound of formula (III), including the reaction of a compound of formula (I) with compounds of formula (II) in the presence of an acid catalyst, where X represents –N= or CR³; R¹ is hydrogen or C_6-10 aryl optionally substituted with C_1-6 alkyl or C_1-6 alkoxy; R² is hydrogen, C_1-6 alkyl, -YR¹⁰, NR¹¹₂; Y is a single bond or -S-; R¹⁰ is C_1-6 alkyl, C_2-6 alkenyl, C_2-6 alkynyl, C_1-6 alkyl-C_6-10 aryl, C_1-6 alkyl-C_3-8 cycloalkyl, 5-6 membered heteroaryl containing 1-2 heteroatoms selected from nitrogen and sulfur, or C_6-10 aryl optionally substituted with alkyl, C_1-6 alkoxy or nitro; R¹¹ is hydrogen or two R¹¹ together with N combine to form morpholinyl; R⁴ is hydrogen or C_1-6 alkyl; or R¹ and R³ form an annelated benzene ring; R⁶ and R⁸ are hydrogen; R is C_1-6 alkyl or C_2-6 alkenyl; or two R groups together form (CH₂)_m; or one or two R groups together with R⁶ and/or R⁸ form one or two (CH₂)_n groups; n is an integer from 2 to 3; m is an integer from 4 to 5 to form a compound of formula (III).

EFFECT: new effective method for obtaining a compound of formula (III) with a high yield.

6 cl, 27 ex