FIELD: organic chemistry.
SUBSTANCE: method for obtaining 3-aroyl-4-hydroxy-1-(2-hydroxyaryl)-1',3'-dimethylspiro[pyrrole-2,5'-pyrrolo[2,3- d]pyrimidine]-2',4',5 ,6'( 1H, 1'H, 3'H, 7'H)-tetraones of Formula 2a-b by the reaction of 3-aroylpyrrolo[2,1- c][1,4]benzoxazine-1,2,4-triones 1a-b with 6-amino-1,3-dimethylpyrimidine-2,4(1H, 3H)-dione, carried out by keeping the reagents at room temperature in ethyl acetate according to the following scheme:
1, 2: R= H, Ar = Ph (а); R= H, Ar = C6H4F-4 (b).
EFFECT: development of a method for producing 3-aroyl-4-hydroxy-1-(2-hydroxyaryl)-1',3'-dimethylspiro[pyrrole-2,5'-pyrrolo[2,3-d]pyrimidine]-2', 4', 5, 6'(1H, 1'H, 3'H, 7'H)-tetraones with previously unknown antimicrobial activity.
1 cl, 1 tbl, 3 ex
| Title |
Year |
Author |
Number |
| 1,6'-DIARYL-3-AROYL-4-HYDROXY-1',3'-DIMETHYLSPIRO[PIRROLE-2,5'-PYRROLO[2,3-d]PYRIMIDINE]-2',4',5(1H,1'H,3'H)-TRIONES AND METHOD FOR PRODUCTION THEREOF |
2012 |
- Silajchev Pavel Sergeevich
- Maslivets Andrej Nikolaevich
- Makhmudov Ramiz Ragibovich
|
RU2502738C2 |
| METHOD OF PRODUCING 9-AROYL-8-HYDROXY-6-(2-HYDROXYARYL)-3-PHENYL-1,3,6-TRIAZASPIRO[4.4]NON-8-ENE-2,4,7-TRIONES HAVING ANTIMICROBIAL ACTIVITY |
2021 |
- Maslivets Andrej Nikolaevich
- Balandina Svetlana Yurevna
- Kobelev Aleksandr Ivanovich
- Babikova Natalya Vladimirovna
|
RU2767558C1 |
| METHOD OF PRODUCING 9-AROYL-8-HYDROXY-6-(2-HYDROXYARYL)-1,3-DIPHENYL-1,3,6-TRIAZASPIRO[4.4]NON-8-ENE-2,4,7-TRIONES, HAVING ANTIMICROBIAL ACTIVITY |
2021 |
- Maslivets Andrej Nikolaevich
- Balandina Svetlana Yurevna
- Kobelev Aleksandr Ivanovich
- Babikova Natalya Vladimirovna
|
RU2767555C1 |
| APPLICATION OF 1-(2-HYDROXY-5-CHLOROPHENYL)-4-PHENYL-6-THIOXO-5,6-DIHYDRO-1H-PYRROLO[3,2-c]PYRIDINE-2,3-DIONE AS AN ANTIMICROBIAL ACTIVITY |
2022 |
- Maslivets Andrei Nikolaevich
- Balandina Svetlana Iurevna
- Kobelev Aleksandr Ivanovich
|
RU2785345C1 |
| METHOD FOR PREPARING 1-ALKYL-6,6-DIMETHYL-2,4-DIOXO-2,3,4,5,6,7-HEXAHYDRO-1H-INDOLE-3-SPIRO-2-( 1-ARYL-3-AROYL-4-HYDROXY-5-OXO-2,5-DIHYDROPYRROLS) |
2003 |
- Bannikova Ju.N.
- Maslivets A.N.
|
RU2238272C1 |
| 1-AROYLOXY-4-HYDROXY-3-OXO-1,2,3,4,4a,5,6,7,8,8a-DECAHYDROQUINOXALIN-2-SPIRO(1-o-HYDROXYPHENYL-4,5-DIOXO-2,3,4,5-TETRAHYDROPYRROLES) AND METHOD FOR THEIR PREPARING |
2007 |
- Mashevskaja Irina Vladimirovna
- Maslivets Andrej Nikolaevich
- Tikhonov Aleksej Jakovlevich
- Mazhukin Dmitrij Gennad'Evich
|
RU2320660C1 |
| 5-METHYL-2-OXO-1-PHENYL-4-ETHOXYCARBONYL-2,3-DIHYDRO-1H-PYRROLE-3-SPIRO-2-(3-BENZOYL-4-HYDROXY-1-ORTHO-HYDROXYPHENYL-5-OXO-2,5-DIHYDROPYRROLES) ELICITING ANTIMICROBIAL ACTIVITY WITH RESPECT TO GRAM-POSITIVE MICROFLORA AND METHOD FOR THEIR PREPARING |
2005 |
- Maslivets Andrej Nikolaevich
- Racheva Nadezhda L'Vovna
- Belevich Irina Olegovna
|
RU2294330C1 |
| 3-AROYL-4-HYDROXY-1-(2-HYDROXYPHENYL)-5',5'-DIMETHYLDISPIRO[2,5-DIHYDRO-1H-AZOL-2,2'-(2',5',6',7-TETRAHYDRO-3'H-AZOLO[1,2-a]AZOL) 7',1"-(1",4"-DIHYDRONAPHTHALENE)]-3',4",5-TRIONES AND METHOD FOR PREPARING THEM |
2011 |
- Konovalova Valerija Vladislavovna
- Maslivets Andrej Nikolaevich
- Shkljaev Jurij Vladimirovich
- Makhmudov Ramiz Ragibovich
|
RU2485123C1 |
| METHOD FOR PRODUCING (R*)-3-AROYL-2-HYDROXY-2-((S*)-2-OXOCYCLOALKYL)PYRROLO[1,2-A]QUINOXALINE-1,4(2H,5H)-DIONES |
2018 |
- Maslivets Andrej Nikolaevich
- Kasatkina Svetlana Olegovna
- Stepanova Ekaterina Evgenevna
- Balandina Svetlana Yurevna
|
RU2665060C1 |
| METHOD FOR PRODUCING 4-AROYL-1-(2-HYDROXYARYL)-5-(1H-INDOL-3-YL)-1,3-DIHYDRO-2H-PYRROLE-2,3-DIONES WITH ANTIMICROBIAL ACTIVITY |
2023 |
- Maslivets Andrei Nikolaevich
- Balandina Svetlana Iurevna
- Kobelev Aleksandr Ivanovich
- Karavaev Danil Aleksandrovich
|
RU2806040C1 |
