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2 806 432

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IPC

C12N15/00(2006-01-01)

C12Q1/686(2018-01-01)

G01N33/574(2006-01-01)

G01N33/53(2006-01-01)

(21) (22)

Application

2021130592, 2021-10-20

(24)

Start date

2021-10-20

(22)

Actual filing date

2021-10-20

(45)

Published

2023-10-31

(72)

Inventor

Karpukhin Aleksandr VasilevichKipkeeva Fatimat MagomedovnaMuzaffarova Tatyana Aleksandrovna

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Nauchnoe Uchrezhdenie Nauchnyj Tsentr Imeni Akademika N.P. Bochkova»

METHOD OF PREDICTING METASTASIS OF STOMACH CANCER TUMORS Russian patent published in 2023 - IPC C12N15/00 C12Q1/686 G01N33/574 G01N33/53

Abstract RU 2806432 C2

FIELD: biotechnology.

SUBSTANCE: method of predicting metastasis of gastric cancer tumors is described, the said method includes the stages of obtaining tissue samples of gastric cancer tumors and normal gastric mucosa tissue, performing reverse transcription of microRNAs from miR-34a, miR-146a, miR-335 and miR-590 and mRNA groups of the VEGF R 1 gene group, VEGF R2, NRP1, determining the expression levels of the above microRNAs and mRNA, comparing the expression levels of the above microRNAs and mRNA relative to normal gastric mucosa and determining the risk of gastric cancer tumor metastasis.

EFFECT: expansion of the ability to predict distant metastases of gastric cancer and increase in the reliability of this prediction by studying the expression of microRNAs and genes.

8 cl, 2 dwg, 6 tbl, 6 ex

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RU 2 806 432 C2

Authors

Karpukhin Aleksandr Vasilevich

Kipkeeva Fatimat Magomedovna

Muzaffarova Tatyana Aleksandrovna

Dates

2023-10-31—Published

2021-10-20—Filed