FIELD: pharmaceuticals.
SUBSTANCE: invention relates to a method of producing phenylacetylene from styrene in two stages. The method is characterized by the fact that the oxidative bromination of styrene is initially carried out at a molar ratio of the following reagents: potassium bromide: phosphoric acid:hydrogen peroxide:styrene equal to 1:2:3:0.33, with the formation of 1,2-dibromo-2-ethylbenzene which is then dehydrobrominated using potassium hydroxide in a molar ratio of 1:(2.4–2.5) in N-methylpyrrolidone for 1–2 hours at a temperature of 120–130°C, and the resulting potassium bromide is returned to the technological cycle.
EFFECT: developed method makes it possible to obtain the target product with a yield of more than 80% and a content of the main substance above 99%.
1 cl, 2 ex, 2 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PRODUCTION OF 1,2-DIBROM-3,5-DINITROBENZENE | 1991 |
|
RU2053220C1 |
| METHOD AND SYSTEM FOR PRODUCTION OF HEXAFLUORO -1,3-BUTADIENE | 2023 |
|
RU2817152C1 |
| ANTIPYRENE COMPOSITION FOR USE IN POLYSTYRENES | 2008 |
|
RU2455324C2 |
| METHOD OF PROCESSING CONDENSATE OF HIGH-TEMPERATURE PYROLYSIS OF SATURATED C3- C5-HYDROCARBONS | 2002 |
|
RU2215021C1 |
| 0 |
|
SU406827A1 | |
| BROMATED BUTADIENE/VINYLAROMATIC COPOLYMERS, MIXTURES OF SAID COPOLYMERS WITH VINYLAROMATIC POLYMER AND POLYMER FOAMED MATERIALS MADE FROM SAID MIXTURES | 2006 |
|
RU2414479C2 |
| PROCESS FOR PREPARING (±)-6-CYANO-3,4-DIHYDRO-2,2- DIMETHYL-TRANS-4-(2-OXO-1-PYRROLIDINYL)-2H-1-BENZOPYRAN- 3-OL | 1992 |
|
RU2041223C1 |
| METHOD FOR PRODUCING HALOGEN POLYFLUOROBENZENES | 2018 |
|
RU2687554C1 |
| METHOD FOR BROMINATION OF XYLENES INTO RING | 2015 |
|
RU2601752C1 |
| METHOD OF PRODUCING MODIFIED DIENE-CONTAINING (CO)POLYMER | 2019 |
|
RU2732776C1 |
