METHOD FOR PREDICTING THE RISK OF DEVELOPING RESPIRATORY FAILURE IN PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA WITH UNDERLYING SARS-CoV2 INFECTION Russian patent published in 2024 - IPC G01N33/68 A61B5/205 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to pulmonology, preventive medicine, and can be used to predict the risk of developing respiratory failure in patients with community-acquired pneumonia with underlying SARS-CoV2 infection. General clinical state of the patient is determined and blood is analysed. Blood serum is analysed for activity of elastase-like and trypsin-like proteinases. Prediction of the risk of developing respiratory failure is calculated by formula (P): P=1/(1+e^-H), where e=2.718. H is calculated by the logistic regression equation: H(x₁, x₂, x₃, x₄)=-3.370+b₁x₁+b₂x₂+b₃x₃+b₄x₄, where b₁=0.003; b₂=0.001; b₃=-1.682; b₄=1.646; x₁ is activity of elastase-like proteinases, nmol BANE/min⋅ml; x₂ is activity of trypsin-like proteinases, nmol BAEE/min⋅ml; x₃ is type 2 diabetes mellitus: absence – 0, presence – 1; x₄ is nature of disease course: mild – 1, moderate – 3, severe – 4; and if P is more than 0.5, a high risk of developing respiratory failure is predicted.

EFFECT: method provides the possibility of increasing the information value of the prediction of the risk of developing respiratory failure in the patients with community-acquired pneumonia with SARS-CoV2 infection by studying biologically active molecules – determining the activity of elastase-like and trypsin-like proteinases in blood serum, as well as the nature of the clinical course of the disease and the presence of type 2 diabetes mellitus.

1 cl, 7 dwg, 3 ex