METHOD FOR DETERMINING MAGNITUDE OF PRESSURE PULSE IN VOLUME OF BLOOD FLOW IN AREA OF MACULA AND OPTIC NERVE DISC Russian patent published in 2023 - IPC A61B5/02 A61B3/12 

FIELD: ophthalmology.

SUBSTANCE: intended to determine the magnitude of pressure pulse in the volume of blood flow in the area of the macula and optic nerve disc. First, optical coherence tomography angiography (OCTA) is performed with a number of scans of 512 and a scanning area of 3x3 mm. The volume of microcirculatory blood flow in the scanning area is determined. Layers are distinguished by depth, 0.25 mm thick, and each layer is assigned a coefficient that determines the contribution of the signal from it to the volume of microcirculatory blood flow. Laser speckle flowgraphy (LSFG) is performed. The amplitude of the pulse wave is calculated at each point in the image of the study area. The image of the study area obtained during OCTA examination is superimposed on the image of the LSFG area. Then, at each point of the OCTA scan array in which there is a vascular network, the amplitude of pulse oscillations is determined as the product of the amplitude of the LSFG signal at this point of the fundus and the coefficient corresponding to this layer in depth. Based on the obtained amplitude values, the magnitude of the pressure pulse is determined by summing the amplitude values at each image point in the three-dimensional region under study.

EFFECT: providing a quantitative assessment of the magnitude of pressure pulse in blood flow volume in any selected three-dimensional area of the macula and optic nerve disc through the combined use of OCTA and LSFG.

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