FIELD: biotechnology.
SUBSTANCE: following is described: a group of inventions including a synthetic oncolytic virus, a pharmaceutical composition for the treatment of a malignant tumor (variants), and a method of treating a malignant tumor in a subject in need. The synthetic oncolytic virus has a lipid nanoparticle containing N1,N3,N5-tris(3-(didodecylamino)propyl)benzene-1,3,5-tricarboxamide (TT3) and a self-amplifying RNA replicon containing the sequence encoding the interleukin (IL)-molecule 12.
EFFECT: invention expands the arsenal of agents aimed at treating a malignant tumor in a subject in need.
17 cl, 5 dwg, 1 tbl, 5 ex
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