ALLOSTERIC PHARMACOLOGICAL CHAPERONE THAT RESTORES FUNCTION OF GLUCOCEREBROSIDASE Russian patent published in 2023 - IPC C07C235/64 A61K31/175 A61P25/16 A61P7/00 

Abstract RU 2809824 C1

FIELD: medicine.

SUBSTANCE: invention relates to an allosteric pharmacological chaperone that restores the function of glucocerebrosidase, from the class of N,O-disubstituted sacylyloyl hydrazine derivatives, general formula.

EFFECT: creation of a new compound that restores the function of glucocerebrosidase due to allosteric regulation, which can be used in medicine for the treatment of Gaucher disease and Parkinson's disease.

1 cl, 5 dwg

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RU 2 809 824 C1

Authors

Bajdakova Galina Viktorovna

Bojtsov Vitalij Mikhajlovich

Emelyanov Anton Konstantinovich

Zakharova Ekaterina Yurevna

Ibatullin Farid Minikasimovich

Izyumchenko Artem Dmitrievich

Kopytova Alena Eduardovna

Milyukhina Irina Valentinovna

Nikolaev Mikhail Andreevich

Pchelina Sofya Nikolaevna

Rychkov Georgij Nikolaevich

Cheblokov Aleksandr Aleksandrovich

Dates

2023-12-19Published

2023-09-08Filed