METHOD OF DIAGNOSING GENETIC PREDISPOSITION TO DEVELOPMENT OF PHENOMENON OF CORONARY MICROVASCULAR OBSTRUCTION DURING PERCUTANEOUS CORONARY INTERVENTIONS IN PATIENTS WITH MYOCARDIAL INFARCTION WITH ST SEGMENT ELEVATION Russian patent published in 2024 - IPC G01N33/58 C12Q1/6827 C12Q1/686 C12Q1/6876 C12Q1/6883 

FIELD: medicine; cardiology; X-ray endovascular surgery and molecular genetic diagnostics.

SUBSTANCE: invention can be used to diagnose genetic predisposition to the development of the phenomenon of coronary microvascular obstruction (CMSO) when performing percutaneous coronary interventions (PCI) in patients with elevated myocardial infarction ST segment (STEMI). Whole peripheral blood is collected. The genotypes of single nucleotide polymorphisms 1378G>T of the ADD1 gene, -344C>T of the CYP11B2 gene, 677C>T of the MTHFR gene are determined using the polymerase chain reaction method. When a combination is identified: genotype GT or TT 1378G>T in the ADD1 gene, genotype CC -344C>T in the CYP11B2 gene, genotype CC 677C>T in the MTHFR gene, the presence of a genetic predisposition to the development of the phenomenon of coronary microvascular obstruction is established.

EFFECT: method provides diagnosis of hereditary predisposition to the development of CMSO when performing PCI in patients with STEMI by determining the genotypes of single nucleotide polymorphisms 1378G>T of the ADD1 gene, -344C>T of the CYP11B2 gene and 677C>T of the MTHFR gene.

1 cl, 3 ex