FIELD: medicine.
SUBSTANCE: to predict the primary adentiae DNA is extricate out of venous blood lymphocytes. Genotyping of polymorphisms of gene Glutathione S-transferase Ml (GSTM1) and locus 677C> T (Ala222Val) of methylenetetrahydrofolate reductase gene (MTHFR) is carried out using the method of polymerase chain reaction. At detection of gene deletions GSTM1 in combination with homozygous in mutation genotype of MTHFR*TT risk of primary adentiae is predicted.
EFFECT: method enables to carry out an accurate prediction of the disease through the identification of molecular genetic markers.
1 tbl, 2 ex
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