FIELD: regenerative medicine.
SUBSTANCE: invention relates to a method of obtaining a biological analogue of a peripheral nerve in an experiment. The method of obtaining a biological analogue of a peripheral nerve in an experiment, including taking dermis samples from the surface of pig skin, differs in the following way: dermis samples are frozen at a temperature of -(70÷ 80)°C with subsequent defrosting, the samples are treated with a 3.2–5.0% alkaline solution of sodium hydroxide at room temperature at a hydromodulus of 1:5 for 20–24 hours, after which they are washed in 0.05% acetic acid to a neutral pH value for 35–40 hours and fill the NeuraGen collagen tube (INTEGRA, USA).
EFFECT: invention makes it possible to obtain a new biological conduit, which eliminates tension in the area of connection of the damaged section of the nerve, which leads to a reduction in the recovery time of the nerve, a decrease in the number of postoperative complications, and the invention also eliminates the use of synthetic materials.
1 cl, 2 ex
| Title | Year | Author | Number | 
|---|---|---|---|
| METHOD OF DECELLULARIZATION OF PIG DERMIS FOR RECONSTRUCTIVE PLASTIC SURGERY | 2022 | 
 | RU2791987C1 | 
| METHOD FOR PREPARING PORCINE DERMIS FOR CREATING ACELLULAR DERMAL MATRIX IN EXPERIMENT | 2021 | 
 | RU2768156C1 | 
| METHOD OF DECELLULARIZATION OF PERIPHERAL NERVE FOR RECONSTRUCTIVE SURGERY IN EXPERIMENT | 2023 | 
 | RU2815380C1 | 
| METHOD OF PRODUCING ACELLULAR DERMAL MATRIX | 2019 | 
 | RU2717088C1 | 
| METHOD OF RECOVERING AN EXTENDED NERVE DEFECT WITH THE OF AN EPINEURAL CONDUIT | 2016 | 
 | RU2687767C2 | 
| BIORESORBABLE IMPLANT FOR REGENERATION OF PERIPHERAL NERVES | 2023 | 
 | RU2805813C1 | 
| METHOD FOR NERVE REGENERATION STIMULATION | 2021 | 
 | RU2775886C1 | 
| METHOD FOR PRODUCTION OF CELL-FREE MATRIX OF DERMA FOR FURTHER RECONSTRUCTION OF EXTENSIVE DEFECTS OF SOFT TISSUES | 2018 | 
 | RU2704489C1 | 
| NERVE AUTOGRAFT SAMPLING METHOD | 2019 | 
 | RU2716758C1 | 
| INJECTION HETEROGENIC BIOPOLYMER HYDROGEL FOR SUBSTITUTIONAL AND REGENERATIVE SURGERY AND METHOD OF ITS OBTAINING | 2010 | 
 | RU2433828C1 | 
Authors
Dates
2024-03-12—Published
2023-06-27—Filed