RADIATION OF INTRATUMORAL ALPHA EMITTER AND ACTIVATION OF CYTOPLASMIC RECEPTORS TO INTRACELLULAR PATHOGEN Russian patent published in 2024 - IPC A61N5/10 A61K31/4406 A61K31/706 A61K31/713 A61K51/12 A61P35/00 

Abstract RU 2819734 C2

FIELD: medicine.

SUBSTANCE: invention relates to oncology and can be used for tumour treatment. Method according to the invention involves administering to a patient a substance comprising a pathogen simulator - polyinosine: polycytidylic acid (polyIC) with a delivery agent - polyethyleneimine (PEI) and treating the tumour with an intratumoural alpha emitter for 72 hours after the introduction of said substance.

EFFECT: use of the invention allows reducing the tumour size due to synergistic interaction between activation of cytoplasmic receptors to intracellular pathogens (ACSIP) and radiotherapy with an intratumoural alpha emitter.

34 cl, 1 tbl, 3 dwg

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RU 2 819 734 C2

Authors

Domankevich Vered

Keisari Yona

Kelson Itzhak

Dates

2024-05-23Published

2019-10-31Filed