FIELD: biotechnology.
SUBSTANCE: present invention relates to novel species-selective phage endolysins and their use for treating bacterial vaginosis (BV). Present invention provides recombinant endolysins, that is endolysins with substituted domains. Invention also relates to said endolysins for use in treating diseases or disorders, such as bacterial infections, particularly BV. Invention also relates to polynucleotides coding said endolysins. Said polynucleotides can also be used to treat such diseases or disorders. Present invention also discloses a pharmaceutical composition containing endolysin according to the present invention for use in treating such diseases or disorders. Said endolysins, polynucleotides and the pharmaceutical composition can be administered locally, particularly locally in the vagina.
EFFECT: invention provides methods of treating, decontaminating or detecting bacterial infections and disorders associated with Gardnerella.
27 cl, 16 dwg, 7 tbl, 7 ex
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