TRANSGENIC ANIMALS AND METHODS OF USE Russian patent published in 2016 - IPC A01K67/27

Abstract RU 2580017 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology and genetic engineering. Description of transgenic mouse having a genome comprising introduced human immunoglobulin region part, wherein said region contains introduced sequences encoding human V_H noncoding sequences and V_H based on endogenous mouse genome. Said mouse is capable of expressing antibody chains with human variable regions. Also method for producing such mouse is described.

EFFECT: invention can be used in immunology.

6 cl, 11 dwg, 6 ex

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RU 2 580 017 C2

Authors

Uobl Mattias

Killin Najdzhel

Dates

2016-04-10—Published

2011-07-26—Filed