RESTRICTED IMMUNOGLOBULIN HEAVY CHAIN MICE Russian patent published in 2016 - IPC A01K67/27 C12N5/10 C07K16/18

Abstract RU 2603090 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology. Mice having a restricted immunoglobulin heavy chain locus are provided. Locus is characterized by a single polymorphic human V_H gene segment, a plurality of human D_H gene segments and a plurality of J_H gene segments. Methods for making antibody sequences that bind an antigen are provided, comprising immunizing a mouse with an antigen of interest.

EFFECT: presented group of inventions can be applied in medicine.

39 cl, 24 dwg, 9 tbl, 4 ex

Similar patents RU2603090C2

Title	Year	Author	Number
HUMANIZED NON-HUMAN ANIMALS WITH RESTRICTED IMMUNOGLOBULIN HEAVY CHAIN LOCI	2013	Macdonald Lynn Mcwhirter John Tu Naxin Stevens Sean Murphy Andrew J.	RU2656155C2
MICE WITH LIMITED HEAVY CHAIN IMMUNOGLOBULIN	2012	Makdonald Linn Makuirter Dzhon Gyurer Kagan Miger, Karolina, A. Merfi Endryu Dzhej	RU2743589C2
HUMANISED LIGHT CHAIN MICE	2012	Macdonald Lynn Gurer Cagan Hosiawa Karolina A. Stevens Sean Murphy Andrew J.	RU2664181C2
NON-HUMAN ANIMALS EXPRESSING PH-SENSITIVE IMMUNOGLOBULIN SEQUENCES	2013	Mcwhirter John Macdonald Lynn Martin Joel H. Murphy Andrew J.	RU2664473C2
NON-HUMAN ANIMALS WITH CONSTRUCTED LIGHT CHAIN OF LAMBDA IMMUNOGLOBULIN, AND THEIR USE	2018	Murphy, Andrew J. Macdonald, Lynn Guo, Chunguang Mcwhirter, John	RU2778410C2
MICE WITH HUMANIZED LIGHT CHAIN	2012	Macdonald, Lynn Gurer, Cagan Hosiawa, Karolina, A. Stevens, Sean Murphy, Andrew, J.	RU2761639C2
ADAM6 MICE	2012	Makdonald Linn Stivens Shon Merfi Endrju Dzh.	RU2582261C2
COMMON LIGHT CHAIN MOUSE	2013	Babb Robert Mcwhirter John Macdonald Lynn Stevens Sean Davis Samuel Buckler David R. Meagher Karolina A. Murphy Andrew J.	RU2683514C2
MICE EXPRESSING LIMITED IMMUNOGLOBULIN LIGHT CHAIN REPERTOIRE	2014	Babb Robert Mcwhirter John Macdonald Lynn Stevens Sean Davis Samuel Buckler David R. Meagher Karolina A. Murphy Andrew J.	RU2689664C2
ADAM6 MICE	2012	Makdonald Linn Stivens Shon Merfi Endryu Dzh.	RU2722373C2

RU 2 603 090 C2

Authors

Macdonald Lynn

Mcwhirter John

Gurer Cagan

Hosiawa Karolina A.

Murphy Andrew J.

Dates

2016-11-20—Published

2012-10-17—Filed