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2 821 104

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IPC

C07D233/74(2006-01-01)

C07D233/96(2006-01-01)

A61K31/4166(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2023132332, 2023-12-08

(24)

Start date

2023-12-08

(22)

Actual filing date

2023-12-08

(45)

Published

2024-06-17

(72)

Inventor

Cheresiz Sergei VladimirovichKovaleva Kseniia SergeevnaIarovaia Olga IvanovnaSalakhutdinov Nariman FaridovichPokrovskii Andrei Georgievich

(73)

Holder

Federalnoe Gosudarstvennoe Biudzhetnoe Uchrezhdenie Nauki Novosibirskii Institut Organicheskoi Khimii Im. N.N. Vorozhtsova Sibirskogo Otdeleniia Rossiiskoi Akademii Nauk So Ran)Federalnoe Gosudarstvennoe Avtonomnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniia Natsionalnyi Issledovatelskii Gosudarstvennyi Universitet"

DERIVATIVES OF IMIDAZOLIDINE-2,4-DIONE AND IMIDAZOLIDINE-2,4,5-TRIONE BASED ON RESIN ACIDS, EXHIBITING ANTI-INVASIVE ACTIVITY ON GLIOBLASTOMA CELLS OF T98G AND SNB-19 LINES Russian patent published in 2024 - IPC C07D233/74 C07D233/96 A61K31/4166 A61P35/00

Abstract RU 2821104 C1

FIELD: molecular biology; biochemistry; medicine; pharmacology.

SUBSTANCE: invention relates to imidazolidine-2,4-dione and imidazolidine-2,4,5-trione derivatives, which are 1-(((1R,4aS,10aR)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl)methyl)-3-phenylimidazolidine-2,4-dione (I) and 1-(2-adamantyl)-3-((1R,4aS,10aR)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-yl)imidazolidine-2,4,5-trion (II).

EFFECT: compounds of formulas (I) and (II), which are capable in non-cytotoxic concentrations to reduce the ability of GBM cells of grafted lines to migration (in scratch overgrowth test) by 30–37%.

1 cl, 4 dwg, 2 tbl, 4 ex

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RU 2 821 104 C1

Authors

Cheresiz Sergei Vladimirovich

Kovaleva Kseniia Sergeevna

Iarovaia Olga Ivanovna

Salakhutdinov Nariman Faridovich

Pokrovskii Andrei Georgievich

Dates

2024-06-17—Published

2023-12-08—Filed