METHOD FOR DETERMINING TOPOGRAPHIC POSITION OF PANCREAS IN LABORATORY MICE BY LIFETIME RADIATION IMAGING IN THREE-MODAL SYSTEM Russian patent published in 2024 - IPC A61B6/03 G09B23/28 G01T1/164 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to experimental oncology and radiation imaging, and can be used to determine the topographic position of the pancreas of a laboratory mouse by lifetime radiation imaging. Two days before the study, experimental mice are intravenously injected with 200 mcl of a preparation of gold nanoparticles with a gold concentration of 110 mg/ml and an average size of gold nanoparticles of 9 nm, coated with a biocompatible polymer. In the stomach of experimental mice, a radiopaque agent is orally introduced through a probe, for the preparation of which the radiopaque iodine-containing preparation is diluted with water so that the iodine concentration in solution is 150 mg/ml, based on the obtained solution, a preparation of a jelly-like consistency based on corn starch with 1% dry substance concentration is prepared. Radiopaque agent is introduced in several stages in dosages: 100 mcl for one day, 150 mcl for 2 hours, 60 mcl for 15 minutes before the beginning of the study. 10 minutes before the examination, 100 mcl of a radiopaque iodine-containing preparation with iodine concentration of 300 mg/ml is administered intravenously. Immediately before the examination, a radiopharmaceutical preparation having pancreatic tissue tropism is administered in dose of 16.6 MBq. Computed tomography (CT) and positron emission tomography (PET) consisting of 8 time frames with duration of 15 min in a three-modal system are performed successively. On the combined PET/CT images, an image of the pancreas is obtained in the form of a hyperfixation zone of the radiopharmaceutical drug, and the organs topographically adjacent to the pancreas accumulate radiopaque drugs.

EFFECT: method enables to establish the pancreas topography features, identify and delineate the organ for further analysis by successively excluding syntopic abdominal organs from the interpretation area, image of which is obtained by introducing radiopaque preparations.

1 cl, 3 dwg, 1 ex