FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, in particular to a genetically modified mouse whose genome contains, in an endogenous immunoglobulin kappa light chain locus, an exogenous gene sequence of a kappa light chain variable region, wherein the exogenous gene sequence of the kappa light chain variable region contains only one human IGKV gene and only one human IGKJ gene, as well as to a cell derived therefrom.
EFFECT: invention is effective for antibody production.
19 cl, 35 dwg, 22 tbl, 13 ex
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