METHOD FOR SYNTHESIS OF ROD-SHAPED MAGNETITE NANOPARTICLES Russian patent published in 2024 - IPC C01G49/08 A61K33/26 A61K49/18 A61P35/00 B82Y40/00 B82Y30/00 B82Y5/00 

FIELD: obtaining nanostructures.

SUBSTANCE: invention relates to production of nanostructures which can be used in medicine. In the process of magnetite nanoparticles synthesis of a rod shape, nanorods are first formed β-FeOOH by hydrolysis of an aqueous solution of FeCl₃ in autoclave at 120°C for 3 hours. Nanorods β-FeOOH is deposited on a centrifuge, the precipitates are washed with deionised water and ethanol, after which they are dried in a vacuum cabinet. Cleaned dried nanorods β-FeOOH is dispersed using an ultrasonic bath in 20 ml of glycerine for 15 minutes, in which 0.2 g of polyethylene glycol (PEG) with molecular weight 4,000 Da is preliminary dissolved. Obtained viscous suspension is placed in an autoclave and subjected to hydrothermal treatment for 2 hours at temperature of 200°C. Obtained magnetite Fe₃O₄ nanorods are collected from the solution with a permanent magnet and washed with deionised water and ethanol. 20 ml of sodium polyacrylate (PAA) solution with molecular weight of 5,100 Da with concentration of 12 mg/ml is added to the cleaned particles, suspension is incubated for a day with constant stirring on a magnetic mixer. Magnetite nanorods are deposited with a magnet, washed with deionised water from non-adsorbed polymer and dispersed in 0.9% NaCl solution.

EFFECT: invention increases environmental friendliness of synthesis of biocompatible nanorods of Fe₃O₄, having high monodispersity and magnetisation.

3 cl, 4 dwg, 3 tbl