FIELD: medicine; organic chemistry.
SUBSTANCE: invention relates to organic chemistry and medicine, specifically to individual 1-[(5-nitrofuran-2-yl)carbonyl]-2'-propyl-1H,7'H-spiro[azetidine-3,5'-furo[3,4d]pyrimidine] of formula 1, having anti-tuberculosis activity with respect to a multidrug-resistant agent, as well as a method for preparing it.
EFFECT: obtaining a novel compound of formula 1, which can potentially be used in medicine as a drug, developing a method for synthesis thereof, as well as detected anti-tuberculosis activity in vitro with respect to standard and clinical drug-resistant strains of Mycobacterium tuberculosis.
2 cl, 6 dwg, 2 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| 1-[(5-NITROFURAN-2-YL)CARBONYL]-2'-PHENYL-1H,7'H-SPIRO[AZETIDINE-3,5'-FURO[3,4-D]PYRIMIDINE], HAVING ANTI-TUBERCULOSIS ACTIVITY IN WITH RESPECT TO MULTIDRUG-RESISTANT TUBERCULOSIS AGENT, AND METHOD FOR PRODUCTION THEREOF | 2023 |
|
RU2824815C1 |
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|
RU2825647C1 |
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|
RU2825646C1 |
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|
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|
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|
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