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2 825 646

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IPC

C07D487/10(2006-01-01)

A61K31/4196(2006-01-01)

A61P31/06(2006-01-01)

(21) (22)

Application

2023123064, 2023-09-04

(24)

Start date

2023-09-04

(22)

Actual filing date

2023-09-04

(45)

Published

2024-08-28

(72)

Inventor

Lukin Aleksej YurevichVinogradova Tatyana IvanovnaDogonadze Marine ZaurievnaKomarova Kristina YurevnaVinogradova Lyubov VladimirovnaDarin Dmitrij ViktorovichLavrova Anastasiya IgorevnaPostnikov Evgenij BorisovichSychev Aleksandr VladimirovichYablonskij Petr Kazimirovich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauchno-Issledovatelskij Institut Ftiziopulmonologii" Ministerstva Zdravookhraneniya Rossijskoj Federatsii

COMPOUND OF 8-(4-METHYL-4H-1,2,4-TRIAZOL-3-YL)-6-(METHYLSULPHONYL)-2-(5-NITRO-2-FUROYL)-2,6-DIAZASPIRO[3.4]OCTANE, HAVING ANTI-TUBERCULOSIS ACTIVITY AGAINST MULTIDRUG-RESISTANT TUBERCULOSIS AGENT, AND METHOD FOR PRODUCTION THEREOF Russian patent published in 2024 - IPC C07D487/10 A61K31/4196 A61P31/06

Abstract RU 2825646 C1

FIELD: organic chemistry; medicine.

SUBSTANCE: invention relates to individual 8-(4-methyl-4H-1,2,4-triazol-3-yl)-6-(methylsulphonyl)-2-(5-nitro-2-furoyl)-2,6-diazaspiro[3.4]octane of formula 1. Compound of formula 1 has antituberculous activity against tuberculosis agent. Invention also relates to a method of producing said compound.

EFFECT: obtaining a compound of formula 1 with confirmed in vitro anti-tuberculosis activity with respect to standard and clinical strains of Mycobacterium tuberculosis with multiple drug resistance, not showing cytotoxic action on macroorganism cells and characterized by good tolerance and harmlessness.

2 cl, 6 dwg, 3 tbl, 4 ex

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RU 2 825 646 C1

Authors

Lukin Aleksej Yurevich

Vinogradova Tatyana Ivanovna

Dogonadze Marine Zaurievna

Komarova Kristina Yurevna

Vinogradova Lyubov Vladimirovna

Darin Dmitrij Viktorovich

Lavrova Anastasiya Igorevna

Postnikov Evgenij Borisovich

Sychev Aleksandr Vladimirovich

Yablonskij Petr Kazimirovich

Dates

2024-08-28—Published

2023-09-04—Filed