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2 824 815

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IPC

C07D491/20(2006-01-01)

A61K31/519(2006-01-01)

A61P31/06(2006-01-01)

(21) (22)

Application

2023130229, 2023-11-20

(24)

Start date

2023-11-20

(22)

Actual filing date

2023-11-20

(45)

Published

2024-08-14

(72)

Inventor

Lukin Aleksej YurevichVinogradova Tatyana IvanovnaDogonadze Marine ZaurievnaVinogradova Lyubov VladimirovnaKomarova Kristina YurevnaDarin Dmitrij ViktorovichZabolotnykh Natalya VyacheslavovnaLavrova Anastasiya IgorevnaPostnikov Evgenij BorisovichGlukhov Dmitrij AleksandrovichSychev Aleksandr VladimirovichYablonskij Petr Kazimirovich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauchno-Issledovatelskij Institut Ftiziopulmonologii" Ministerstva Zdravookhraneniya Rossijskoj Federatsii

1-[(5-NITROFURAN-2-YL)CARBONYL]-2'-PHENYL-1H,7'H-SPIRO[AZETIDINE-3,5'-FURO[3,4-D]PYRIMIDINE], HAVING ANTI-TUBERCULOSIS ACTIVITY IN WITH RESPECT TO MULTIDRUG-RESISTANT TUBERCULOSIS AGENT, AND METHOD FOR PRODUCTION THEREOF Russian patent published in 2024 - IPC C07D491/20 A61K31/519 A61P31/06

Abstract RU 2824815 C1

FIELD: organic chemistry; medicine.

SUBSTANCE: invention relates to individual 1-[(5-nitrofuran-2-yl)carbonyl]-2'-phenyl-1/H,7'H-spiro[azetidine-3,5'-furo[3,4-d]pyrimidine] formula 1, having anti-tuberculosis activity with respect to a multidrug-resistant agent, as well as a method for preparing it.

EFFECT: obtaining a novel compound of formula 1, which can potentially be used in medicine as a drug, developing a method for synthesis thereof, as well as detected anti-tuberculosis activity in vitro with respect to standard and clinical drug-resistant strains of Mycobacterium tuberculosis.

2 cl, 6 dwg, 2 tbl, 4 ex

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RU 2 824 815 C1

Authors

Lukin Aleksej Yurevich

Vinogradova Tatyana Ivanovna

Dogonadze Marine Zaurievna

Vinogradova Lyubov Vladimirovna

Komarova Kristina Yurevna

Darin Dmitrij Viktorovich

Zabolotnykh Natalya Vyacheslavovna

Lavrova Anastasiya Igorevna

Postnikov Evgenij Borisovich

Glukhov Dmitrij Aleksandrovich

Sychev Aleksandr Vladimirovich

Yablonskij Petr Kazimirovich

Dates

2024-08-14—Published

2023-11-20—Filed