FIELD: medicine.
SUBSTANCE: group of inventions relates to the treatment of cancer. Composition for treating cancer consists of at least 90 wt.% from atropisomer of formula (1) or a pharmaceutically acceptable salt or tautomer thereof; by 0-10 wt.% from atropisomer of formula (2) or its pharmaceutically acceptable salt or its tautomer:
, 
Also disclosed is a single atropisomer, a pharmaceutical composition for treating a cancer, use thereof for treating a cancer in which PLK1 and/or PLK4 are involved, use as a PLK1-PBD and/or PLK4-PBD inhibitor, use in preparing a drug for treating a cancer disease, a method of treating a cancer disease, a method for preparing a composition or a single atropisomer.
EFFECT: group of inventions provides effective treatment of cancer.
18 cl, 13 dwg, 16 tbl, 11 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PHARMACEUTICAL COMPOUND | 2018 |
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| HETEROAROMATIC COMPOUNDS AS PHOSPHATIDYLINOSITOL 3-KINASE MODULATORS | 2014 |
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| COMBINATION THERAPY | 2013 |
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| AMINOPYRIMIDINE KINASE INHIBITORS | 2012 |
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RU2669696C2 |
