FIELD: biotechnology.
SUBSTANCE: disclosed are: a chimeric antigen receptor (CAR) polypeptide, which binds to a B-lymphocyte antigen, comprising a B-lymphocyte antigen-binding domain, which contains a defined amino acid sequence, nucleic acid coding CAR polypeptide, expression vector containing nucleic acid and immune cell expressing CAR polypeptide. Also disclosed is a method of treating cancer, using a composition for adoptive immunotherapy containing CAR-expressing cells for treating cancer and for preparing a drug for treating cancer.
EFFECT: invention is used to treat cancer associated with a B-lymphocyte antigen in a subject.
17 cl, 16 dwg, 14 tbl, 6 ex
| Title | Year | Author | Number |
|---|---|---|---|
| COMPOSITIONS AND METHODS FOR BOOSTING THE EFFECTIVENESS OF ADOPTIVE CELL IMMUNOTHERAPY | 2015 |
|
RU2716716C2 |
| METHODS OF EXPANSION OF ANTIGEN-SPECIFIC CAR-T-CELLS, COMPOSITIONS AND THEIR USE | 2019 |
|
RU2800920C2 |
| CHIMERIC ANTIGEN RECEPTORS AND THEIR PRODUCTION METHODS | 2015 |
|
RU2753965C2 |
| LABELED CHIMERIC EFFECTOR MOLECULES AND RECEPTORS THEREOF | 2014 |
|
RU2729463C2 |
| CHIMERIC ANTIGEN RECEPTORS WITH MUTATED CD28 COSTIMULATION DOMAINS | 2018 |
|
RU2800922C2 |
| CHIMERIC ANTIGEN RECEPTOR T-CELLS (CAR-T) FOR CANCER TREATMENT | 2019 |
|
RU2811466C2 |
| COMBINATION THERAPY FOR THE TREATMENT OF BCMA-RELATED CANCER AND AUTOIMMUNE DISORDERS | 2018 |
|
RU2799762C2 |
| CHIMERIC RECEPTORS CONTAINING TRAF-6-INDUCING DOMAINS AND COMPOSITIONS AND METHODS RELATED TO THEM | 2016 |
|
RU2773159C2 |
| NON-HUMAN ANIMALS EXPRESSING HUMANISED COMPLEX CD3 | 2015 |
|
RU2726446C2 |
| IMPROVED METHODS FOR PRODUCING ADOPTIVE CELL THERAPY AGENTS | 2015 |
|
RU2741899C2 |
