BIODEGRADABLE TWO-LAYER MATRIX FOR PREVENTING FORMATION OF POST-SURGICAL ADHESIONS, PARTICULARLY IN HERNIOPLASTY Russian patent published in 2024 - IPC A61L31/06 A61L31/10 A61L31/14 

FIELD: chemistry.

SUBSTANCE: group of inventions relates to biodegradable matrix (14) for preventing the formation of postoperative adhesions in the body of a mammal, comprising upper layer (16) made of a first biocompatible polymer material containing polylactic acid as a main component; and lower layer (18) made of a second biocompatible polymer material containing poly (glycolic acid-lactic acid) as a main component; wherein the content of polylactic acid in the first polymer material is higher than in the second polymer material; both layers (16, 18) are formed in the form of porous frames containing a spongy structure with interconnected pores of different sizes, upper layer (16) is hydrophilic and has a wetting angle less than 75° and lower layer (18) is hydrophobic and has a wetting angle of more than 90°, and also relates to a method of producing a matrix by a) obtaining a first mixture of I salt particles and a dissolved first polymer material containing polylactic acid as a main component; b) applying a first mixture I to a surface to form a first layer; c) obtaining a second mixture II of salt particles and a dissolved second polymer material containing poly(glycolic acid-lactic acid) as a main component, wherein the content of polylactic acid in the first polymer material is higher than in the second polymer material; d) applying a layer of the second mixture II obtained in step c) on top of the first layer obtained in step b); e) drying the obtained structure to obtain a two-layer biodegradable matrix (14) with lower layer (18) of a second polymer material and upper layer (16) of a first polymer material; and f) plasma treatment of matrix (14) using plasma of oxidised gas at temperature below 50 °C.

EFFECT: group of inventions provides hernia closure without adhesion formation.

16 cl, 1 dwg