FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing novel 1'-aryl-1-benzyl-4'-hydroxy-6,6-dimethyl-3'-cinnamoyl-6,7-dihydrospiro[indole-3,2'-pyrrole]-2,4,5'(1H,1'H,5H)-triones and 1,1'-diaryl-4'-hydroxy-6,6-dimethyl-3'-cinnamoyl-6,7-dihydrospiro[indole-3,2'-pyrrole]-2,4,5'(1H,1'H,5H)-triones of formula: 
, where Ar denotes C6H4OMe-4, C6H4Me-4; R denotes Ph, C6H4Me-4, C6H4OMe-4, C6H4Br-4, Bn, by reacting 1-aryl-3-cinnamoyl-4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylate with N-substituted 3-amino-5,5-dimethylcyclohex-2-ene in a medium of an inert aprotic solvent - toluene, at temperature of 108-110°C for 15-20 min.
EFFECT: obtaining a novel analgesic substance.
1 tbl, 3 ex
| Title |
Year |
Author |
Number |
| 1'-ARYL-4'-HYDROXY-3'-CYNNAMOYL-2H,4H-SPIRO[FURO[3,2-c]CHROMEN-3,2'-PYRROL]-2,4,5'(1'H)-TRIONES EXHIBITING ANALGESIC ACTIVITY, AND METHOD FOR PRODUCING THEM |
2014 |
- Silajchev Pavel Sergeevich
- Filimonov Valerij Olegovich
- Maslivets Andrej Nikolaevich
- Makhmudov Ramiz Ragibovich
|
RU2577523C2 |
| 3'-AROYL-1-BENZYL-4'-HYDROXY-1'-(2-HYDROXYETHYL)-6,6-DIMETHYL-6,7-DIHYDROSPIRO[INDOLO-3,2'-PYRROLE]-2,4,5'(1H,1'H,5H)-TRIONES POSSESSING ANALGESIC ACTIVITY AND A METHOD FOR THEIR PREPARATION |
2018 |
- Tretyakov Nikita Alekseevich
- Maslivets Andrej Nikolaevich
- Makhmudov Ramiz Ragibovich
- Galeev Andrej Ruslanovich
|
RU2688931C1 |
| APPLICATION OF 1-BENZYL-4'-HYDROXY-1'-(2-HYDROXYETHYL)-3'- (METHOXYBENZOYL)-6,6-DIMETHYL-6,7-DIHYDROSPIRO[INDOLE-3,2'-PYRROLE] 2,4 ,5'(1H,1'H,5H)-TRIONE AS AN AGENT WITH ANTIHYPOXIC ACTIVITY |
2021 |
- Maslivets Andrej Nikolaevich
- Tretyakov Nikita Alekseevich
- Makhmudov Ramiz Ragibovich
|
RU2763738C1 |
| 1,6'-DIARYL-3-AROYL-4-HYDROXY-1',3'-DIMETHYLSPIRO[PIRROLE-2,5'-PYRROLO[2,3-d]PYRIMIDINE]-2',4',5(1H,1'H,3'H)-TRIONES AND METHOD FOR PRODUCTION THEREOF |
2012 |
- Silajchev Pavel Sergeevich
- Maslivets Andrej Nikolaevich
- Makhmudov Ramiz Ragibovich
|
RU2502738C2 |
| 1,1'-DIARYL-3'-AROYL-4'-HYDROXY-1H-SPIRO [INDENO[1,2-b]PYRROL-3,2'-PYRROL]-2,4,5'-(1'H)-TRIONES AND METHOD OF THEIR OBTAINING |
2011 |
- Bubnov Nikolaj Vladimirovich
- Denislamova Ekaterina Sergeevna
- Makhmudov Ramiz Ragibovich
- Maslivets Andrej Nikolaevich
|
RU2467011C1 |
| METHYL 1-ARYL-3-HYDROXY-3'-METHYL-2,4,5'-TRIOXO-6-PHENYL-2,4,5,6-TETRAHYDRO-5'H-SPIRO[INDOLE-7,4'-ISOXAZOLE]-7a(1H)-CARBOXYLATES, METHYL 1-ARYL-(1'-PHENYL AND 1'-BENZYL)-3-HYDROXY-3'-METHYL-2,4,5'-TRIOXO-6-PHENYL-1',2,4,5,5',6-HEXAHYDROSPIRO[INDOLE-7,4'-PYRAZOLE]-7a(1H)-CARBOXYLATES AND METHYL 1'-ARYL-3'-HYDROXY-1,2',3,4'-TETRAOXO-6'-PHENYL-1,2',3,4',5',6'-HEXAHYDROSPIRO[INDENE-2,7'-INDOLE]-7a'(1'H)-CARBOXYLATES, DEMONSTRATING ANALGESIC ACTIVITY AND METHOD FOR OBTAINING THEREOF |
2014 |
- Silajchev Pavel Sergeevich
- Filimonov Valerij Olegovich
- Maslivets Andrej Nikolaevich
- Makhmudov Ramiz Ragibovich
|
RU2577528C2 |
| METHYL 3-METHYL-5-[2-(4-ARYLAMINO)-2-OXOACETYL]-1,6-DIPHENYL-1H-PYRAZOLO[3,4-b]PYRIDINE-4-CARBOXYLATES AND METHYL 3-METHYL-5-[2-(4-ARYLAMINO)-2-OXOACETYL]-6-STYRYL-1-PHENYL-1H-PYRAZOLO[3,4-b]PYRIDINE-4-CARBOXYLATES AND METHOD FOR PREPARING THEM |
2012 |
- Maslivets Andrej Nikolaevich
- Bubnov Nikolaj Vladimirovich
- Silajchev Pavel Sergeevich
- Filimonov Valerij Olegovich
- Makhmudov Ramiz Ragibovich
|
RU2495039C1 |
| 6,6-DIMETHYL-8-OXO-5,6,8,9-TETRAHYDROBENZO[F]-PYRROLO[2,1-ALPHA]ISOQUINOLINE-9-SPIRO-2-(3-AROYL-4-HYDROXY-1-O-HYDROXYPHENYL-5-OXO-2,5-DIHYDRO-1H-PYRROLES) AND 6,6-DIMETHYL-8-OXO-5,6,8,9-TETRAHYDROBENZO[F]PYRROLO[2,1-ALPHA]ISOQUINOLINE-9-SPIRO-2-(3-BENZOYL-4-HYDROXY-1-O-HYDROXYPHENYL-5-OXO-2,5-DIHYDRIO-1H-PYRROLE) ELICITING ANALGESIC ACTIVITY AND METHOD FOR THEIR PREPARING |
2006 |
- Anikina Lada Vladimirovna
- Racheva Nadezhda L'Vovna
- Maslivets Andrej Nikolaevich
- Shkljaev Jurij Vladimirovich
|
RU2316557C1 |
| APPLICATION OF 3'- BENZOYL-4'-HYDROXY-1'-(2-HYDROXYPHENYL)-6,6-DIMETHYL-6,7-DIHYDRO-2Н-SPIRO-[1-BENZOFURAN-3,2'-PYRROLE]-2,4,5'(1'H,5H)- TRION, AS A MEANS HAVING GROWTH-REGULATING ACTIVITY IN RELATION TO THE CULTURE OF CHLORELLA VULGARIS |
2021 |
- Maslivets Andrej Nikolaevich
- Khramtsova Ekaterina Evgenevna
- Lystsova Ekaterina Aleksandrovna
- Belyaeva Polina Gennadevna
- Galyamina Valentina Vladimirovna
- Tseshinskaya Ekaterina Mikhajlovna
- Sharavin Dmitrij Yurevich
|
RU2764905C1 |
| METHOD FOR PREPARING 1-ALKYL-6,6-DIMETHYL-2,4-DIOXO-2,3,4,5,6,7-HEXAHYDRO-1H-INDOLE-3-SPIRO-2-( 1-ARYL-3-AROYL-4-HYDROXY-5-OXO-2,5-DIHYDROPYRROLS) |
2003 |
- Bannikova Ju.N.
- Maslivets A.N.
|
RU2238272C1 |
