FIELD: pharmaceutics.
SUBSTANCE: present invention relates to novel compounds, pharmaceutical compositions containing them, and their use in therapy, particularly in the prevention or treatment of hearing disorders, as well as schizophrenia, substance abuse, pain and fragile X chromosome. Disclosed is a compound of formula (I) or a salt thereof, where R1 is H or methyl; R2 and R3 are both methyl, or R2 and R3, together with the carbon atom to which they are attached, form a spirocyclopropyl ring; R4 is methyl or ethyl; R5 is H or methyl; or R4 and R5, together with the carbon atom to which they are attached, form C3-C4 spirocarbocyclyl. Invention also relates to use of said compound, intermediate compounds thereof, as well as a pharmaceutical composition and a method of treating based thereon.
EFFECT: obtaining alternative compounds for treating disorders in which a Kv3,1 and/or Kv3,2 and/or Kv3,3 modulator is required.
43 cl, 15 ex
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