Show metadata Hide metadata

(19)

(11)

2 830 480

(13)

(51)

IPC

A61K31/4184(2006-01-01)

A61K31/4422(2006-01-01)

A61K39/395(2006-01-01)

A61P9/12(2006-01-01)

A61P43/00(2006-01-01)

G09B23/28(2006-01-01)

(21) (22)

Application

2024104903, 2024-02-27

(24)

Start date

2024-02-27

(22)

Actual filing date

2024-02-27

(45)

Published

2024-11-19

(72)

Inventor

Khliamov Stanislav ValerevichArtiushkova Elena BorisovnaMal Galina SergeevnaGladchenko Mikhail Petrovich

(73)

Holder

Federalnoe Gosudarstvennoe Biudzhetnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniia Gosudarstvennyi Meditsinskii Universitet" Ministerstva Zdravookhraneniia Rossiiskoi Federatsii

METHOD FOR CORRECTION OF BEVACIZUMAB-INDUCED ARTERIAL HYPERTENSION BY UNFIXED COMBINATION OF TELMISARTAN AND AMLODIPINE Russian patent published in 2024 - IPC A61K31/4184 A61K31/4422 A61K39/395 A61P9/12 A61P43/00 G09B23/28

Abstract RU 2830480 C1

FIELD: medicine.

SUBSTANCE: invention refers to experimental medicine, namely to cardiology. Arterial hypertension is simulated in male Wistar rats by intraperitoneal introduction of bevacizumab in dose of 15 mg/kg a week. When a cumulative dose is reached—60 mg/kg intragastrically daily 1 time day for 20 days, an unfixed combination of preparations is administered, consisting of telmisartan in dose of 3.1 mg/kg and amlodipine in dose of 0.4 mg/kg.

EFFECT: method enables to correct bevacizumab-induced arterial hypertension using a non-fixed combination of preparations, which, in turn, makes it possible to expand the list of agents used to correct bevacizumab-induced arterial hypertension.

1 cl, 1 tbl, 1 ex

Similar patents RU2830480C1

Title	Year	Author	Number
METHOD OF CORRECTING HYPERHOMOCYSTEINE-INDUCED ENDOTHELIAL DYSFUNCTION BY MEDICATION "PHOSPHOGLIV" CAPSULES	2010	Pokrovskij Mikhail Vladimirovich Korokin Mikhail Viktorovich Artjushkova Elena Borisovna Gudyrev Oleg Sergeevich Pokrovskaja Tat'Jana Grigor'Evna Korokina Lilija Viktorovna Belous Aleksandr Sergeevich Kochkarov Vladimir Iskhakovich Danilenko Ljudmila Mikhajlovna Gladchenko Mikhail Petrovich Gureev Vladimir Vladimirovich Kolesnik Inga Mikhajlovna Stabrovskaja Nadezhda Vladimirovna Ragulina Vera Alekseevna Ivanov Aleksandr Viktorovich Jakushev Vladimir Ivanovich Korolev Anton Evgen'Evich Polonskaja Ksenija Vadimovna	RU2430428C1
METHOD FOR CORRECTION OF ENDOTHELIAL DYSFUNCTION BY COMBINATION OF AMLODIPINE AND L-ARGININE IN L-NAME-INDUCED DEFICIENCY OF NITROGEN OXIDE	2005	Pokrovskij Mikhail Vladimirovich Kochkarov Vladimir Iskhakovich Pokrovskaja Tat'Jana Grigor'Evna Gladchenko Mikhail Petrovich Artjushkova Elena Borisovna Novikov Oleg Olegovich Afanas'Ev Jurij Ivanovich Zhiljakova Elena Teodorovna Pashin Evgenij Nikolaevich Tikhova Ljubov' Ivanovna Danilenko Ljudmila Mikhajlovna Rykova Nina Ivanovna Korokina Lilija Viktorovna Gureeva Elena Gennad'Evna Majakov Aleksandr Igorevich Mikaeljan Pavel Keropovich Muljar Aleksandr Georgievich Metel'Skaja Viktorija Alekseevna Gumanova Nadezhda Georgievna Filippenko Nikolaj Grigor'Evich	RU2296566C1
METHOD FOR COMBINED TADALAFIL AND L-NORVALINE CORRECTION OF L-NAME INDUCED NITROGEN OXIDE DEFICIENCY IN EXPERIMENT	2012	Dudina Ehleonora Nikolaevna Chernomortseva Elena Stanislavovna Pokrovskij Mikhail Vladimirovich Pokrovskaja Tat'Jana Grigor'Evna Belous Aleksandr Sergeevich Konovalova Elena Anatol'Evna Kljavs Petr Janovich Litvjakova Marija Igorevna Litvjakova Evgenija Igorevna Gureev Vladimir Vladimirovich	RU2500040C1
METHOD OF TADALAFIL-BASED CORRECTION OF ENDOTHELIAL DYSFUNCTION IN L-NAME INDUCED NITRIC OXIDE DEFICIENCY	2008	Pokrovskij Mikhail Vladimirovich Chuljukova Tat'Jana Nikolaevna Pokrovskaja Tat'Jana Grigor'Evna Kochkarov Vladimir Iskhakovich Gladchenko Mikhail Petrovich Artjushkova Elena Borisovna Novikov Oleg Olegovich Novikova Marina Jur'Evna Prusachenko Vladimir Konstantinovich Grimova Taisija Aleksandrovna Denisjuk Tat'Jana Alekseevna Lazarenko Galina Stepanovna Gureev Vladimir Vladimirovich Tsepelev Vasilij Jur'Evich Belous Aleksandr Sergeevich Korokin Mikhail Viktorovich Gudyrev Oleg Sergeevich Tsybul'Skij Igor' Valer'Evich Luchkina Elena Vadimovna Ershov Il'Ja Nikolaevich Khardikova Elena Mikhajlovna	RU2364395C1
MEDICATION FOR CORRECTION OF ENDOTHELIAL DYSFUNCTION	2011	Ehpshtejn Oleg Il'Ich Sergeeva Svetlana Aleksandrovna Zabolotneva Julija Aleksandrovna	RU2536228C2
METHOD FOR CORRECTION OF ENDOTHELIAL DYSFUNCTION WITH PREPARATION PHOSPHOGLIV LYOPHILIZATE IN L-NAME INDUCED NITROGEN OXIDE DEFICIENCY	2008	Pokrovskij Mikhail Vladimirovich Artjushkova Elena Borisovna Pokrovskaja Tat'Jana Grigor'Evna Kochkarov Vladimir Iskhakovich Gureev Vladimir Vladimirovich Korokin Mikhail Viktorovich Gladchenko Mikhail Petrovich Korokina Lilija Viktorovna Artjushkova Ekaterina Vjacheslavovna Belous Aleksandr Sergeevich Malykhin Vitalij Alekseevich Kedrovskaja Natalija Aleksandrovna Polonskaja Ksenija Vadimovna Pashkova Irina Aleksandrovna Tsepelev Vasilij Jur'Evich Gudyrev Oleg Sergeevich	RU2372078C1
METHOD OF ENDOTHELIAL DYSFUNCTION CORRECTION BY COMBINATION OF TRIMETAZIDINE AND L-ARGININE IN L-NAME-INDUCED NITROGEN OXIDE DEFICIENCY	2009	Pokrovskij Mikhail Vladimirovich Pokrovskaja Tat'Jana Grigor'Evna Artjushkova Elena Borisovna Artjushkova Ekaterina Vjacheslavovna Korokina Lilija Viktorovna Korokin Mikhail Viktorovich Gudyrev Oleg Sergeevich Gladchenko Mikhail Petrovich Gureev Vladimir Vladimirovich Tsepelev Vasilij Jur'Evich Grimova Taisija Aleksandrovna Kochkarov Vladimir Iskhakovich Danilenko Ljudmila Mikhajlovna Belous Aleksandr Sergeevich Polonskaja Ksenija Vadimovna	RU2421822C2
METHOD FOR L-NORVALINE CORRECTION OF L-NAME INDUCED NITROGEN OXIDE DEFICIENCY IN EXPERIMENT	2010	Pokrovskij Mikhail Vladimirovich Pokrovskaja Tat'Jana Grigor'Evna Tsepeleva Svetlana Aleksandrovna Tsepelev Vasilij Jur'Evich Belous Aleksandr Sergeevich Korokin Mikhail Viktorovich Gudyrev Oleg Sergeevich Gureev Vladimir Vladimirovich Lopatin Dmitrij Vladimirovich Korokina Lilija Viktorovna Titareva Ljudmila Viktorovna Losenok Polina Igorevna Denisjuk Tat'Jana Alekseevna Poljanskaja Oksana Sergeevna	RU2449783C2
METHOD FOR ENDOTHELIAL DYSFUNCTION CORRECTION	2011	Ehpshtejn Oleg Il'Ich Sergeeva Svetlana Aleksandrovna Zabolotneva Julija Aleksandrovna	RU2541166C2
METHOD OF CORRECTION OF ENDOTHELIAL DYSFUNCTION BY PHOSPHOGLIV PREPARATION AT L-NAME INDUCED DEFICIENCY OF NITROGEN OXIDE	2008	Pokrovskij Mikhail Vladimirovich Artjushkova Elena Borisovna Pokrovskaja Tat'Jana Grigor'Evna Kochkarov Vladimir Iskhakovich Gureev Vladimir Vladimirovich Korokin Mikhail Viktorovich Gladchenko Mikhail Petrovich Korokina Lilija Viktorovna Artjushkova Ekaterina Vjacheslavovna Belous Aleksandr Sergeevich Malykhin Vitalij Alekseevich Kedrovskaja Natalija Aleksandrovna Polonskaja Ksenija Vadimovna Pashkova Irina Aleksandrovna Tsepelev Vasilij Jur'Evich Gudyrev Oleg Sergeevich	RU2359668C1

RU 2 830 480 C1

Authors

Khliamov Stanislav Valerevich

Artiushkova Elena Borisovna

Mal Galina Sergeevna

Gladchenko Mikhail Petrovich

Dates

2024-11-19—Published

2024-02-27—Filed