METHOD FOR CORRECTION OF ENDOTHELIAL DYSFUNCTION BY COMBINATION OF AMLODIPINE AND L-ARGININE IN L-NAME-INDUCED DEFICIENCY OF NITROGEN OXIDE Russian patent published in 2007 - IPC A61K31/4422 A61K31/197 A61P9/12 

Abstract RU 2296566 C1

FIELD: medicine, experimental cardiopharmacology.

SUBSTANCE: dysfunction is modeled in experiment by every day intraperitoneal administration to rats of L-arginine nitromethyl ester for 7 days in the dose 25 mg/kg. On this background amlodipine is administrated into stomach in the dose 0.5 mg/kg, and L-arginine is administrated by intraperitoneal route in the dose 200 mg/kg once per 24 h. Method provides effective correction under the definite modeling conditions.

EFFECT: improved method of dysfunction correction.

2 tbl, 1 ex

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RU 2 296 566 C1

Authors

Pokrovskij Mikhail Vladimirovich

Kochkarov Vladimir Iskhakovich

Pokrovskaja Tat'Jana Grigor'Evna

Gladchenko Mikhail Petrovich

Artjushkova Elena Borisovna

Novikov Oleg Olegovich

Afanas'Ev Jurij Ivanovich

Zhiljakova Elena Teodorovna

Pashin Evgenij Nikolaevich

Tikhova Ljubov' Ivanovna

Danilenko Ljudmila Mikhajlovna

Rykova Nina Ivanovna

Korokina Lilija Viktorovna

Gureeva Elena Gennad'Evna

Majakov Aleksandr Igorevich

Mikaeljan Pavel Keropovich

Muljar Aleksandr Georgievich

Metel'Skaja Viktorija Alekseevna

Gumanova Nadezhda Georgievna

Filippenko Nikolaj Grigor'Evich

Dates

2007-04-10Published

2005-12-28Filed