LIQUID COMPOSITION OF BOTULINUM TOXIN FOR TREATING EYEBROW WRINKLES AND LATERAL PERIORBITAL WRINKLES FROM MODERATE TO SEVERE Russian patent published in 2024 - IPC A61K38/48 A61K47/02 A61K47/18 A61K9/00 A61Q19/08 

FIELD: medicine.

SUBSTANCE: invention relates to treatment of eyebrow wrinkles and lateral periorbital wrinkles. Method of treating eyebrow wrinkles and/or lateral periorbital wrinkles in a human subject involves administering to the subject a therapeutically effective amount of a liquid composition containing botulinum neurotoxin and a chloride ion source selected from NaCl at concentration of 100–300 mM, KCl at concentration of 1–25 mM; more than one source of phosphate ions selected from sodium phosphate, potassium phosphate, anhydrous disodium hydrophosphate, anhydrous sodium dihydrophosphate, at concentration of 1–50 mM; non-ionic surfactant in concentration of 0.01–5.0 (v./v.)%; amino acid stabilizer selected from alanine, valine, leucine, isoleucine, methionine, phenylalanine, tyrosine and tryptophan, in concentration of 0.1–3 mg/ml, wherein the patient is injected with a combination of intramuscular injections of the above composition in the eyebrow region and/or below the lateral eyelid commissure, in the outer part of the orbicularis muscle.

EFFECT: invention provides stable liquid compositions containing botulinum toxin, which can be introduced without reconditioning or mixing.

21 cl, 16 dwg, 35 tbl, 1 ex