FIELD: biotechnology.
SUBSTANCE: disclosed are methods of producing antigen-binding molecules containing an antigen-binding domain, the antigen-binding activity of which varies depending on the concentration of a compound specific for the malignant or inflamed target tissue.
EFFECT: disclosed methods enable to obtain antigen-binding molecules which can be used to treat various diseases which originate from the target tissue in a manner specific for the target tissue.
10 cl, 53 dwg, 24 tbl, 21 ex
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