FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing (E)-5-amino-3-hydrazono-4-hydroxy-1-(2-hydroxyphenyl)-6a-(1H-indol-3-yl)-4-phenylhexahydropyrrolo[3,4-b]pyrrole-2,6-dione of formula II. Method is carried out by holding at 85 °C 3-benzoyl-2-hydroxy-3a-(1H-indol-3-yl)-1H-pyrrolo[2,1-c][1,4]benzoxazine-1,4(3aH)-dione I with hydrazine in molar ratio of 1:2 according to the scheme given below.
EFFECT: method of producing (E)-5-amino-3-hydrazono-4-hydroxy-1-(2-hydroxyphenyl)-6a-(1H-indol-3-yl)-4-phenylhexahydropyrrolo[3,4-b]pyrrole-2,6-dione of formula II, having anti-tuberculosis activity.
1 cl, 1 tbl, 1 ex
| Title |
Year |
Author |
Number |
| METHOD OF PRODUCING 3-HYDROXY-1-(2-HYDROXYPHENYL)-7a-(1H-INDOL-3-YL)-4-PHENYL-1,7a-DIHYDRO-2H-PYRROLO[2,3-d]PYRIDAZINE-2,7(6h)-DIONE AS AGENT HAVING ANTI-TUBERCULOSIS ACTIVITY |
2024 |
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- Balandina Svetlana Iurevna
- Kobelev Aleksandr Ivanovich
|
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2023 |
- Lukmanova Dzhamilia Nailevna
- Mashevskaia Irina Vladimirovna
- Balandina Svetlana Iurevna
|
RU2808987C1 |
| ANTITUBERCULOSIS AGENT BASED ON 4'-HYDROXY-1'-(2-HYDROXYPHENYL)-3'-ACYL-SPIRO[BENZO[b][1,4]THIAZINE-2,2'-PYRROLE]-3,5'(1 'H,4H)-DIONES |
2023 |
- Balandina Svetlana Iurevna
- Lukmanova Dzhamilia Nailevna
- Mashevskaia Irina Vladimirovna
|
RU2806097C1 |
| METHOD OF PRODUCING N,N-DIETHYL-3-BENZOYL-4-HYDROXY-1-(2-HYDROXYPHENYL)-2-(1H-INDOL-3-YL)-5-OXO-2,5-DIHYDRO-1H-PYRROLE-2-CARBOXAMIDE HAVING ANTIMICROBIAL ACTIVITY |
2024 |
- Karavaev Danil Aleksandrovich
- Maslivets Andrei Nikolaevich
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- Kobelev Aleksandr Ivanovich
|
RU2829462C1 |
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2023 |
- Maslivets Andrei Nikolaevich
- Balandina Svetlana Iurevna
- Kobelev Aleksandr Ivanovich
- Karavaev Danil Aleksandrovich
|
RU2806041C1 |
| METHOD FOR PRODUCING 4-AROYL-1-(2-HYDROXYARYL)-5-(1H-INDOL-3-YL)-1,3-DIHYDRO-2H-PYRROLE-2,3-DIONES WITH ANTIMICROBIAL ACTIVITY |
2023 |
- Maslivets Andrei Nikolaevich
- Balandina Svetlana Iurevna
- Kobelev Aleksandr Ivanovich
- Karavaev Danil Aleksandrovich
|
RU2806040C1 |
| ANTI-TUBERCULOSIS AGENT BASED ON 4-((HET)AROYL)-3-HYDROXY-1-(2-HYDROXYPHENYL)-5-(PHENYLTHIO)-1,5-DIHYDRO-2H-PYRROL-2-ONES |
2021 |
- Mashevskaya Irina Vladimirovna
- Balandina Svetlana Yurevna
- Lukmanova Dzhamilya Nailevna
|
RU2767542C1 |
| USE OF 3-ARYL-6H-SPIRO[BENZO[b]FURO[3',4':2,3]PYRROLO[1,2-d][1,4]OXAZINE-5,3'-INDOLINE]-1,2,2',6-TETRAONES AS AGENTS WITH ANTI-TUBERCULOSIS ACTIVITY |
2024 |
- Topanov Pavel Andreevich
- Mashevskaia Irina Vladimirovna
- Balandina Svetlana Iurevna
|
RU2831345C1 |
| 4'-HYDROXY-1'-(2-HYDROXYPHENYL)-3'-(4-R-BENZOYL)SPIRO[BENZO[B][1,4]THIAZINE-2,2'-PYRROLE]-3,5'( 1'H,4H)-DIONE |
2022 |
- Mashevskaia Irina Vladimirovna
- Lukmanova Dzhamilia Nailevna
- Dmitriev Maksim Viktorovich
- Balandina Svetlana Iurevna
|
RU2783263C1 |
| DERIVATIVES OF 3-(2-AMINOETHYL)-4-[3-(TRIFLUOROMETHYL)BENZOYL]- -3,4-DIHYDRO-2H-1,4-BENZOXAZINE, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION CONTAINING ON SAID |
1995 |
- Zhorzh Paskal'
- Frost Dzhonatan
- Paso Patrik
- Russel' Korinn
- Barch Rezhin
- Vil'Jams Pol Khauard
- Mjuller Zhan-Klod
|
RU2136670C1 |
