FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, in particular to a line of genetically modified mice for simulating Alzheimer's disease (AD). Said line is characterized by the fact that in the nucleotide sequence of the grin3a gene, AC nucleotides are deleted in positions corresponding to positions 49844568-49844569 in the sequence of chromosome 4 of the line C57BL/6J Mus musculus of the GRCm39 genome assembly, which contains the said grin3a gene. Invention also relates to a method of producing said line and its use as a model of Alzheimer's disease.
EFFECT: present invention provides a genetically engineered mouse model of AD with exact knockout of grin3a gene, at which expression of other genes is not affected, suitable for detailed study of pathogenesis of AD and preclinical assessment of potential methods of treating AD, intended for use in humans.
11 cl, 2 dwg, 1 ex
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